IL-12 family receptors exert their funcitons by binding to their heterodimeric IL-12 family cytokines which can often act synergistically to promote Th1 responses and interferon-γ (IFN-γ) production by T cells.
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All known IL-12 family members exert their function via receptor chains that are structurally homologous to the gp130 family of "tall" shared cytokine receptors.
Below are IL-12 family ligands, IL-12 subunits, receptors and its functions.
| Ligand | Subunits | Receptor | Function |
| IL-12 | p35+p40 | IL12RB1(CD212), IL12RB2 | Th1 differentiation; Th2 inhibition |
| IL-23 | p19+p40 | IL12RB1(CD212), IL23R / IL23 Receptor | Th17 differentiation |
| IL-27 | p28+EBI3 | IL12RB1(CD212), WSX-1/IL-27R | Th1 differentiation Suppression of Th17; differentiation Stimulation of Tr1 cells |
| IL-35 | p35+EBI3 | IL12RB2, IL6ST/gp130/CD130, WSX-1/IL-27R | Treg proliferation Suppression of Th1 and Th17 cell development |
IL-12 family receptor chains are used by multiple IL-12 family cytokines. IL-12 signals via IL-12Rβ1 and IL-12Rβ2, whereas IL-23 signals via IL-12Rβ1 and IL-23R. On the contrary, IL-27 uses gp130 and IL-27R (WSX-1). whereas IL-35 signals via gp130 and IL-12Rβ2. IL-35 is unusual in that it can also signal via two additional receptor-chain compositions: gp130-gp130 and IL-12Rβ2–lL-12Rβ2 homodimers.
The following are outlines of "IL-12 Family Receptor Review Page", which briefly introduce each member of IL-12 family ligand. If you want more details, please click here.
| • IL-12 Receptor | • IL-27 Receptor |
| • IL-23 Receptor | • IL-35 Receptor |
