IL-12 family receptors exert their funcitons by binding to their heterodimeric IL-12 family cytokines which can often act synergistically to promote Th1 responses and interferon-γ (IFN-γ) production by T cells.
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All known IL-12 family members exert their function via receptor chains that are structurally homologous to the gp130 family of "tall" shared cytokine receptors.
Below are IL-12 family ligands, IL-12 subunits, receptors and its functions.
|IL-12||p35+p40||IL12RB1(CD212), IL12RB2||Th1 differentiation; Th2 inhibition|
|IL-23||p19+p40||IL12RB1(CD212), IL23R / IL23 Receptor||Th17 differentiation|
|IL-27||p28+EBI3||IL12RB1(CD212), WSX-1/IL-27R||Th1 differentiation Suppression of Th17;
differentiation Stimulation of Tr1 cells
|IL-35||p35+EBI3||IL12RB2, IL6ST/gp130/CD130, WSX-1/IL-27R||Treg proliferation Suppression of Th1 and Th17
IL-12 family receptor chains are used by multiple IL-12 family cytokines. IL-12 signals via IL-12Rβ1 and IL-12Rβ2, whereas IL-23 signals via IL-12Rβ1 and IL-23R. On the contrary, IL-27 uses gp130 and IL-27R (WSX-1). whereas IL-35 signals via gp130 and IL-12Rβ2. IL-35 is unusual in that it can also signal via two additional receptor-chain compositions: gp130-gp130 and IL-12Rβ2–lL-12Rβ2 homodimers.
The following are outlines of "IL-12 Family Receptor Review Page", which briefly introduce each member of IL-12 family ligand. If you want more details, please click here.
|• IL-12 Receptor||• IL-27 Receptor|
|• IL-23 Receptor||• IL-35 Receptor|