IL-17 family cytokines must depend on cell surface IL-17 receptors (IL17Rs) for signalling. IL17RA and IL17RC are well-studied members of the IL-17 receptor family in human and mouse models.
As IL-17 receptor proteins possess an intracellular SEFIR domain, upon IL17 ligands binding, this conserved domain directly interacts with Act1 adaptor/ubiquitin ligase to initiate signalling cascades, activating other inflammatory cytokines and chemokines that are usually associated with innate immune responses.
The special capacity for IL-17/IL-17 receptor family members to cooperate with cytokines of innate immunity to promote inflammation implies that they might act as a bridge between innate and adaptive immune systems.
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IL-17 receptor family contains certain conserved structural motifs, including an extracellular fibronectin III-like domain and a cytoplasmic SEFIR (SEF/IL-17R) domain.
IL-17 receptors have little homology to other known cytokine receptors, and are thus classified as new cytokine receptor familiy: IL-17 receptor family.
|IL-17 RA/IL-17 R||IL17A/IL-17A/IL17, IL-17C/IL17C, IL-17E/IL-25, IL-17F||22q11.1|
|IL-17 RB||IL17B/ZCYTO7, IL-17E/IL-25||3p21.1|
|IL-17 RC||IL17A/IL-17A/IL17, IL-17F||3p25.3|
The IL-17 receptor family now consists of 5 members, IL-17RA, IL-17RB, IL-17RC, IL-17RD and IL-17RE, all of which, like their ligands, share sequence homology. Each of these members is a subunit that needs to associate with another one to form the functional receptor. The subunit IL-17RA is ubiquitous, and is encoded by a gene situated on chromosome 22, while others are encoded by a cluster on chromosome 3. It is also a common co-receptor subunit for other members of the IL-17 family.
The following are outlines of "IL-17 Receptor Family Review Page", which briefly introduce each member of IL-17 family ligand. If you want more details, please click here.
|• IL-17 Receptor Family: IL-17RA||• IL-17 Receptor Family: IL-17RC|
|• IL-17 Receptor Family: IL-17RE||• IL-17 Receptor Family: IL-17RB|
|• IL-17 Receptor Family: IL-17RD|