Interleukin-6 (IL-6) family of cytokines includes IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), cardiotrophin-like cytokine (CLC) and cardiotrophin-1 (CT-1). The receptors of the IL-6 family cytokines share a receptor subunit, which explains one of the mechanisms of functional redundancy.
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These cytokines are referred to as IL-6 family because all members of this family utilize glycoprotein 130 as a common signal transducer within their receptor complex that is required for signaling.
| Ligand | Receptor | Chromosome (hu) |
| IL6/IL-6/Interleukin-6 | IL6R/IL-6R/CD126, IL6ST/gp130/CD130 | 7p21-p14 |
| IL-11 / interleukin 11 | IL11RA/IL-11RA, IL6ST/gp130/CD130 | 19q13.3-13.4 |
| IL31/Interleukin-31 | Interleukin-31 receptor A / IL31RA, OSMR/IL-31RB | 12q24.31 |
| CLCF1/NNT-1 | LIFR/CD118, IL6ST/gp130/CD130 | 11q13.2 |
| CNTF/Ciliary Neurotrophic Factor | CNTFR, IL6ST/gp130/CD130, LIFR/CD118, IL6R/IL-6R/CD126, ApoE | 11q12 |
| G-CSF/CSF3 | G-CSF R/CD114/CSF3R | 17q21.1 |
| Cardiotrophin-1/CT-1 | LIFR/CD118, IL6ST/gp130/CD130 | 16p11.1-11.2 |
| Leptin | Leptin Receptor/CD295, Siglec-6 | 7q32.1 |
| Leukemia Inhibitory Factor/LIF | LIFR/CD118, IL6ST/gp130/CD130, IGF2R | 22q14 |
| Oncostatin M/OSM | LIFR/CD118, IL6ST/gp130/CD130, OSMR/IL-31RB | 22q12 |
The IL-6 family of cytokines is a group of functionally and structurally related proteins. These cytokines regulate a variety of complex biological processes, including hematopoiesis, immune response, inflammation, proliferation, differentiation, mammalian reproduction, cardiovascular action, and neuronal survival.
Activation of all cytokines in the IL-6 family involves signaling via the Janus Kinase/Signal Transducer and Activator of Transcription(JAK/STAT) pathway.
The following are outlines of "IL-6 Family Ligand Review Page", which briefly introduce each member of IL-6 family ligand. If you want more details, please click here.
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