IL-6 Family Ligand

Interleukin-6 (IL-6) family of cytokines includes IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), cardiotrophin-like cytokine (CLC) and cardiotrophin-1 (CT-1). The receptors of the IL-6 family cytokines share a receptor subunit, which explains one of the mechanisms of functional redundancy.

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IL-6 Family Ligand Table

These cytokines are referred to as IL-6 family because all members of this family utilize glycoprotein 130 as a common signal transducer within their receptor complex that is required for signaling.

Ligand Receptor Chromosome (hu)
IL6/IL-6/Interleukin-6 IL6R/IL-6R/CD126, IL6ST/gp130/CD130 7p21-p14
IL-11 / interleukin 11 IL11RA/IL-11RA, IL6ST/gp130/CD130 19q13.3-13.4
IL31/Interleukin-31 Interleukin-31 receptor A / IL31RA, OSMR/IL-31RB 12q24.31
CLCF1/NNT-1 LIFR/CD118, IL6ST/gp130/CD130 11q13.2
CNTF/Ciliary Neurotrophic Factor CNTFR, IL6ST/gp130/CD130, LIFR/CD118, IL6R/IL-6R/CD126, ApoE 11q12
G-CSF/CSF3 G-CSF R/CD114/CSF3R 17q21.1
Cardiotrophin-1/CT-1 LIFR/CD118, IL6ST/gp130/CD130 16p11.1-11.2
Leptin Leptin Receptor/CD295, Siglec-6 7q32.1
Leukemia Inhibitory Factor/LIF LIFR/CD118, IL6ST/gp130/CD130, IGF2R 22q14
Oncostatin M/OSM LIFR/CD118, IL6ST/gp130/CD130, OSMR/IL-31RB 22q12

IL-6 Family Ligand Review

The IL-6 family of cytokines is a group of functionally and structurally related proteins. These cytokines regulate a variety of complex biological processes, including hematopoiesis, immune response, inflammation, proliferation, differentiation, mammalian reproduction, cardiovascular action, and neuronal survival.

Activation of all cytokines in the IL-6 family involves signaling via the Janus Kinase/Signal Transducer and Activator of Transcription(JAK/STAT) pathway.

The following are outlines of "IL-6 Family Ligand Review Page", which briefly introduce each member of IL-6 family ligand. If you want more details, please click here.

  • • Interleukin-6
  • • Interleukin-31
  • • Ciliary Neurotrophic Factor
  • • Cardiotrophin-1
  • • Cardiotrophin-Like Cytokine
  • • Granulocyte Colony-Stimulating Factor
  • • Interleukin-11
  • • Oncostatin M
  • • Leukemia Inhibitory Factor
  • • Neuropoeitin
  • • Leptin