The IL-6 family of cytokines signalling through the common receptor subunit gp130 comprises IL-6, IL-11, leukaemia inhibitory factor, oncostatin M, ciliary neurotrophic factor and cardiotrophin-1. These so-called IL-6 family of cytokines play an important role in the regulation of complex cellular processes such as gene activation, proliferation and differentiation.
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These cytokines are referred to as IL-6 family because all members of this family utilize glycoprotein 130 as a common signal transducer within their receptor complex that is required for signaling.
The following table lists every specific IL-6 family ligand, and its corresponding receptors are written on the right side.
|IL-11 / interleukin 11||IL11RA/IL-11RA, IL6ST/gp130/CD130|
|IL31/Interleukin-31||Interleukin-31 receptor A / IL31RA, OSMR/IL-31RB|
|CNTF/Ciliary Neurotrophic Factor||CNTFR, IL6ST/gp130/CD130, LIFR/CD118, IL6R/IL-6R/CD126, ApoE|
|Leptin||Leptin Receptor/CD295, Siglec-6|
|Leukemia Inhibitory Factor/LIF||LIFR/CD118, IL6ST/gp130/CD130, IGF2R|
|Oncostatin M/OSM||LIFR/CD118, IL6ST/gp130/CD130, OSMR/IL-31RB|
IL-6 family receptors are receptors for IL-6 family ligands, including IL-6R/CD126, gp130/IL6ST, ciliary neurotrophic factor receptor (CNTFR) oncostatin M receptor and leukemia inhibitory factor receptor (LIFR). These cytokines function by binding to its receptor complex, which share the same subunit gp130. That's the reason why these cytokines are referred to as IL-6 family.
The following are outlines of "IL-6 Family Receptor Review Page", which briefly introduce each member of IL-6 family ligand. If you want more details, please click here.
|• The IL-6 Receptor Complex||• Other IL-6 Family Receptors|