IL-6 Family Receptor

The IL-6 family of cytokines signalling through the common receptor subunit gp130 comprises IL-6, IL-11, leukaemia inhibitory factor, oncostatin M, ciliary neurotrophic factor and cardiotrophin-1. These so-called IL-6 family of cytokines play an important role in the regulation of complex cellular processes such as gene activation, proliferation and differentiation.

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IL-6 Family Receptor Table

These cytokines are referred to as IL-6 family because all members of this family utilize glycoprotein 130 as a common signal transducer within their receptor complex that is required for signaling.

The following table lists every specific IL-6 family ligand, and its corresponding receptors are written on the right side.

Ligand Receptor
IL6/IL-6/Interleukin-6 IL6R/IL-6R/CD126, IL6ST/gp130/CD130
IL-11 / interleukin 11 IL11RA/IL-11RA, IL6ST/gp130/CD130
IL31/Interleukin-31 Interleukin-31 receptor A / IL31RA, OSMR/IL-31RB
CLCF1/NNT-1 LIFR/CD118, IL6ST/gp130/CD130
CNTF/Ciliary Neurotrophic Factor CNTFR, IL6ST/gp130/CD130, LIFR/CD118, IL6R/IL-6R/CD126, ApoE
Cardiotrophin-1/CT-1 LIFR/CD118, IL6ST/gp130/CD130
Leptin Leptin Receptor/CD295, Siglec-6
Leukemia Inhibitory Factor/LIF LIFR/CD118, IL6ST/gp130/CD130, IGF2R
Oncostatin M/OSM LIFR/CD118, IL6ST/gp130/CD130, OSMR/IL-31RB

IL-6 Family Receptor Review

IL-6 family receptors are receptors for IL-6 family ligands, including IL-6R/CD126, gp130/IL6ST, ciliary neurotrophic factor receptor (CNTFR) oncostatin M receptor and leukemia inhibitory factor receptor (LIFR). These cytokines function by binding to its receptor complex, which share the same subunit gp130. That's the reason why these cytokines are referred to as IL-6 family.

The following are outlines of "IL-6 Family Receptor Review Page", which briefly introduce each member of IL-6 family ligand. If you want more details, please click here.

• The IL-6 Receptor Complex • Other IL-6 Family Receptors