Receptors are proteins, usually cell surface receptors, which bind to a substance (eg. a cytokine) and cause responses in the immune system. Receptors can be found in various immune cells like B cells, T cells, NK cells, monocytes and stem cells, etc.
Receptors can be accessible by anti-receptor antibody which may activate the receptors, mimicking the effect of its genuine ligand, or inhibiting activation by ligands after binding. In addition, anti-receptor antibody has pathogenic importance in several autoimmune diseases, such as Graves' disease, myasthenia gravis, Type B insulin resistance syndrome, and so on. Therefore, researches on anti-receptors antibody may make it possible for therapies of above diseases.
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