Cell activation including T cells, dendritic cells, B cells, granulocytes and NK cells, is an important process in innate and adaptive immune system. Receptors on the surface of these cells help complete whole cell activation process. For example, T cells scan the intracellular environment in order to target and destroy infected cells. Small peptide fragments, representing the entire cellular content, are transported to the cell surface as pMHCs, allowing T cell surface expressed antigen specific TCRs to scan for foreign signals. T cell receptor (TCR) binding to antigen-loaded MHC, both helper T cells and cytotoxic T cells require a number of secondary signals to become activated and respond to the threat.
In B cell activation, the receptor on the surface of B cell is called B cell antigen receptor (BCR). First of all, like the T cell receptor (TCR), B cell receptor (BCR) transmits signals directly to the cell's interior when it binds antigen. Then, the B cell receptor delivers the antigen to intracellular sites where it is degraded and returned to the B cell surface as peptides bound to MHC class II molecules. B cell proliferates and its progeny differentiates into antibody-secreting cells.
Sino biological offers a comprehensive set of tools for receptors related to cell activation research, including recombinant proteins, antibodies (mouse mAbs, rabbit mAbs, and rabbit pAbs), ELISA kits, and ORF cDNA clones.
