Cells interact with each other, and their substrate, throughout their lifetime. These interactions can be transient, such as at the immunological synapse, or they can be long-lived, such as at a neuromuscular junction. These complex cellular structures involve many proteins; from receptor molecules to structural scaffolding proteins. Cell adhesion is generally initiated by one or more of the cell adhesion molecules such as selectins, integrins, syndecans, and cadherins. Intercellular adhesion can be mediated by adherens junctions, tight junctions and desmosomes, whereas cells can interact with extracellular matrix molecules through focal adhesions. To preserve proper tissue architecture, adhesive molecules help maintain contact between nearby cells and structures, and tiny tunnel-like junctions allow the passage of ions and small molecules between adjacent cells. Meanwhile, signaling molecules relay positional information among the cells in a tissue, as well as between these cells and the extracellular matrix. Realization of these biological functions need receptors.
Sino Biological offers a comprehensive set of tools for receptors related to cell adhesion research, including recombinant proteins, antibodies (mouse mAbs, rabbit mAbs, and rabbit pAbs), ELISA kits, and ORF cDNA clones.