Fibroblast Growth Factor Receptor Overview

Fibroblast growth factor receptors (FGF receptors) are single-pass membrane proteins, with N-terminal extracellular (EC) domains consisting of three immunoglobulin-like domains (Ig 1, Ig 2 and Ig 3), a transmembrane (TM) domain consisting of a single α-helix, and an intracellular (IC) region encompassing a tyrosine kinase domain.

Upon ligand binding, FGF receptor, members of growth factor receptors, induces intracellular signaling networks that tightly regulates key biological processes, such as cell proliferation, survival, migration, and differentiation. Deregulation of FGF receptor signaling can thus alter tissue homeostasis and has been associated with several developmental syndromes as well as with many types of cancer. In human cancer, FGF receptors have been found to be deregulated by multiple mechanisms, including aberrant expression, mutations, chromosomal rearrangements, and amplifications.

fgf receptor

FGF Receptor Products List

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