Host Defense Receptors as Drug Targets

Host Defense Receptors as Drug Target Background

Host defense receptors, are referred to these receptors that play a key role in adaptive cellular and humoral immune responses, including complement receptors, Fc receptors and toll-like receptors. These receptors are perfect drug targets for a great many diseases.

CCR1 plays an important role in host defense and is involved in regulating the chemotaxis of immune cells, a feature it shares in common with all chemokine receptors. Dysregulation of this response leads to autoimmunity and CCR1 has been associated with the pathophysiology of a number of diseases including rheumatoid arthritis, multiple sclerosis, transplant rejection and allergic inflammatin.

Host Defense Receptors as Drug Target List

Category Drug target
Complement receptors
Fc receptors
Toll-like receptors
Killer cell immunoglobulin-like receptor
Killer cell lectin-like receptor
Leukocyte immunoglobulin-like receptor
Natural cytotoxicity triggering receptor
Triggering receptor expressed on myeloid cells
Other host defense receptors

References

1. Mannhold R, et al. Chemokine receptors as drug targets[M]. John Wiley & Sons, 2010.

2. Suresh R, et al. Pattern recognition receptors in innate immunity, host defense, and immunopathology[J]. Advances in physiology education, 2013, 37(4): 284-291.