Interleukin receptors are cytokine receptors such as interleukin-1 receptor, interleukin-6 receptor, interleukin-10 receptor, interleukin-12 receptor and interleukin-17 receptor. There are two main families of Interleukin receptors, type 1 and type 2 cytokine receptors. The majority of interleukins are synthesized by helper CD4+ T lymphocytes, as well as through monocytes, macrophages, and endothelial cells. The function of the immune system depends in a large part on interleukins and interleukin receptors. They modulate inflammation and immunity by regulating growth, mobility and differentiation of lymphoid and other cells.
| Interleukin | Interleukin Receptors |
|---|---|
| IL-2 | IL-2Rα, IL-2Rβ, IL-2Rγ |
| IL-3 | IL-3Rα, CSF2RB |
| IL-4 | IL-4R, IL-2Rγ/IL-13Rα1 |
| IL-5 | IL-5Rα, CSF2RB |
| IL-6 | IL-6Rα, gp130 |
| IL-7 | IL-7Rα, IL-2Rγ |
| IL-9 | IL-9R, IL-2Rγ |
| IL-11 | IL-11Rα, gp130 |
| IL-2 | IL-12Rβ1, IL-12Rβ2 |
| IL-13 | IL-13Rα1, IL-13Rα2, IL-4R |
| IL-15 | IL-15Rα, IL-2Rβ, IL-2Rγ |
| IL-16 | CD4, CD9 |
| IL-21 | IL-21R, IL-2Rγ |
| IL-23 | IL-12Rβ1, IL-23R |
| IL-27 | IL-27Rα, gp130 |
| IL-31 | IL-31Rα, OSMR |
| IL-34 | CSF-1R |
| IL-35 | IL-12Rβ2, gp130 |
