Mammalian cells require growth-factor-receptor-initiated signaling to proliferate. Cell Signaling transduction not only initiates entry into the cell cycle, but also reprograms cellular metabolism. This instructional metabolic reprogramming is critical if the cell is to fulfill the anabolic and energetic requirements that accompany cell growth and division.
Mammalian cells require receptor-mediated signaling transduction initiated by extracellular growth factors to leave the quiescent state and enter the cell cycle. The onset of cell growth and division introduces a metabolic requirement for sufficient carbon, nitrogen, and free energy to support synthesis of the new proteins, lipids, and nucleic acids needed by a proliferating cell. There are multiple cell signaling transduction pathway regulating glucose metabolism, including akt signaling, EGFR signaling and HIF1 signaling……More.
Lipid metabolism with many essential lipolytic enzymes, characterization of numerous regulatory proteins and mechanisms have an large significance. Glycerolipid, sphingolipid and sterol cell signaling pathways can cover major lipid metabolism signaling transduction, the misregulation of which may play a pivotal role in human disease……More.
Proliferating cells require a nitrogen source for protein and nucleotide biosynthesis.Mammalian cells acquire nitrogen through the uptake and metabolism of amino acids, using mechanisms that are also highly regulated by cell signaling transduction……More.
• Ward P S, Thompson C B. Signaling in control of cell growth and metabolism[J]. Cold Spring Harbor perspectives in biology, 2012, 4(7): a006783.