Enterovirus 71 (EV71), first isolated in California in 1969, is a member of human enterovirus species A, belongs to genus Enterovirus, family Picornaviridae. More
EV71 is a small non-enveloped virus that contains a positive-sense, single-stranded RNA molecule of approximately 7,400 nucleotides (nt) as its genome. More
The molecular genotyping and epidemiological surveillance of EV71 is conducted by detecting viral VP1. Up to now, three genotypes of EV71 are identified, including genotype A, B and C. More
Since the infection of EV71 primarily affects countries in the Asia-Pacific region, there is little incentive for vaccine companies from developed countries to develop EV71 vaccines, and mainly the companies and institutes in Asia make efforts to take the vaccines from research to product launch. More
First, it is a good way to prevent EV71 infection by blocking its entry. Since the VP1 protein contains most of the neutralizing epitopes and acts as a major receptor-binding protein, it is an ideal antiviral target against EV71. More
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