人乳头瘤病毒(HPV)在全世界引起约5%的癌症病例。
持续感染高风险HPV(HR-HPV),包括 HPV(16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 70, 73, 82)可引起约94%的肛门癌,约63%的阴茎癌,约74%的阴道癌,约5-20%的头颈部鳞状细胞癌以及几乎所有的宫颈癌。
有一些预防性疫苗已被批准用于预防某些类型的HPV感染。疫苗由HPV的主要衣壳蛋白(L1)组装的的病毒样颗粒(VLP)组成。
>95% as determined by SDS-PAGE
Baculovirus-Insect Cells
< 20 EU per mL protein as determined by the LAL method.
货号 | 产品描述 | 应用 | 特异性 |
68009-MM01 | HPV16 L1 Antibody (Conformational Antibody), Mouse MAb | ELISA, IHC-P, FCM, ICC/IF, IF, IP | HPV16 capsid L1 |
载体类型 | HPV39 | HPV51 | HPV53 | HPV56 | HPV59 | HPV68 | HPV73 |
表达载体 | VG40229-UT | VG40230-UT | VG40319-UT | VG40315-UT | VG40231-UT | VG40317-UT | VG40321-UT |
慢病毒表达载体 | VG40229-ACGLN | VG40230-ACGLN | VG40319-ACGLN | VG40315-ACGLN | VG40231-ACGLN | VG40317-ACGLN | VG40321-ACGLN |
• Zhai et al.A Novel Candidate MS2 Phage VLP Vaccine Displaying a tandem HPV L2 Peptide offers Similar Protection in Mice to Gardasil-9.Antiviral Res. 2017 November ; 147: 116–123
• A. Touzeè et al. Production of recombinant virus-like particles from human papillomavirus types 6 and 11, and study of serological reactivities between HPV 6, 11, 16 and 45 by ELISA: implications for papillomavirus prevention and detection. FEMS Microbiology Letters 160 (1998) 111-118
• Stanley M1.HPV vaccination in boys and men.Hum Vaccin Immunother. 2014;10(7):2109-11.
• Stanley MA1, Sterling JC.Host responses to infection with human papillomavirus.Curr Probl Dermatol. 2014;45:58-74.
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