MERS是由致命的人畜共患病毒MERS-CoV引起的中东呼吸综合症,也称为骆驼流感。人们可能通过与骆驼接触而感染病毒。2012年,吉达报道了第一例MERS病例。到目前为止,已经有27个国家出现了MERS-CoV感染病例。
MERS的感染症状有轻有重,其中包括发烧,咳嗽,呼吸急促以及肺炎,致死率高达30%以上。截止到2020年,尚无针对该疾病的特定疫苗或治疗方法,多种抗病毒药物仍在研发中。
MERS-CoV,也称为EMC / 2012(HCoV-EMC / 2012),是正义单链RNA病毒,属于β-CoV。
MERS-CoV具有感染多种人类细胞系的能力。除了肠道,肝细胞和组织细胞外,呼吸道上皮细胞高度易感,肾脏也受到MERS-CoV的显着感染。
MERS-CoV的基因组包含30,119个核苷酸和至少10个开放阅读框。基因组可编码病毒所需的结构蛋白,包括棘突蛋白(S),膜蛋白(M),核衣壳蛋白(N),包膜(E)以及各种辅助蛋白,例如3、4a,4b,5和8b等。
Spike蛋白介导病毒受体识别并诱导病毒感染,因此,spike蛋白是冠状病毒跨物种传播的关键因素。S蛋白N端的受体结合域(RBD)对于β-CoV进入宿主细胞至关重要。并且,感染的严重程度和种间传播的效率均受冠状病毒RBD的影响。
MERS-CoV的功能受体是 二肽基肽酶4(DPP4)。
(Ref: Nour Ramadan, Houssam Shaib.Middle East respiratory syndrome coronavirus (MERS-CoV): A review.GERMS.2019)
Cat# | Antigen | Expressed Host | Tag | Binding Activity | |
Nucleocapsid | Insect | His | |||
S1+S2 ECD | Insect | His | bind DPP4 | ||
S1 Subunit | Insect | His | bind DPP4 | ||
S1 Subunit | HEK293 | His | bind DPP4 | ||
S2 Subunit | Insect | His | |||
40071-V05B |
S-RBD | Insect | mFc | ||
S-RBD | Insect | His | |||
S-RBD | Insect | rFc | |||
S1 Subunit (HPLC-verified) |
HEK293 | His | |||
S-RBD (Biotinylated) | Insect | His |
Cat# | Antigen | More | |||||
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Cat# | Antigen | Ab Type | Application | |
NP-CoV | Mouse MAb | WB, ELISA, IHC-P, FCM, ICC/IF, IP | ||
NP-CoV | Rabbit PAb | ELISA, IHC-P, FCM, ICC/IF, IP | ||
NP-CoV | Rabbit PAb | WB, ELISA, IHC-P, FCM, ICC/IF, IP | ||
NP-CoV | Rabbit PAb | WB, IHC-P, ICC/IF, IP | ||
Spike | Rabbit PAb | WB, IHC-P, ICC/IF, IP | ||
Spike | Rabbit PAb | WB, IHC-P, ICC/IF, IP | ||
Spike | Rabbit PAb | WB, IHC-P, ICC/IF, IP | ||
Spike | Mouse MAb | ELISA, IHC-P, FCM, ICC/IF, IP | ||
Spike | Rabbit MAb | Microneutralizaiton(MN) | ||
Spike | Rabbit PAb | ELISA, IHC-P, FCM, ICC/IF, IP | ||
Spike | Rabbit PAb | ELISA, IHC-P, FCM, ICC/IF, IP | ||
Spike | Rabbit PAb | WB, IHC-P, IP | ||
Spike | Rabbit PAb | WB, ELISA | ||
Spike | Rabbit PAb | WB, ELISA, IP | ||
Spike | Rabbit PAb | WB, ELISA, IHC-P, FCM, ICC/IF, IP | ||
Spike | Mouse MAb | ELISA, IHC-P, FCM, ICC/IF, IP | ||
Spike | Mouse MAb | WB, IHC-P, FCM, ICC/IF, IP | ||
Spike | Rabbit PAb | WB, ELISA, IHC-P, IP |
Cat# | Antigen | More | |||||
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