MERS-CoV

MERS简介

MERS是由致命的人畜共患病毒MERS-CoV引起的中东呼吸综合症,也称为骆驼流感。人们可能通过与骆驼接触而感染病毒。2012年,吉达报道了第一例MERS病例。到目前为止,已经有27个国家出现了MERS-CoV感染病例。

MERS的感染症状有轻有重,其中包括发烧,咳嗽,呼吸急促以及肺炎,致死率高达30%以上。截止到2020年,尚无针对该疾病的特定疫苗或治疗方法,多种抗病毒药物仍在研发中。

MERS-CoV

MERS-CoV,也称为EMC / 2012(HCoV-EMC / 2012),是正义单链RNA病毒,属于β-CoV。

MERS-CoV具有感染多种人类细胞系的能力。除了肠道,肝细胞和组织细胞外,呼吸道上皮细胞高度易感,肾脏也受到MERS-CoV的显着感染。

MERS-CoV的基因组包含30,119个核苷酸和至少10个开放阅读框。基因组可编码病毒所需的结构蛋白,包括棘突蛋白(S),膜蛋白(M),核衣壳蛋白(N),包膜(E)以及各种辅助蛋白,例如3、4a,4b,5和8b等。

Spike蛋白介导病毒受体识别并诱导病毒感染,因此,spike蛋白是冠状病毒跨物种传播的关键因素。S蛋白N端的受体结合域(RBD)对于β-CoV进入宿主细胞至关重要。并且,感染的严重程度和种间传播的效率均受冠状病毒RBD的影响。

MERS-CoV的功能受体是 二肽基肽酶4(DPP4)
(Ref: Nour Ramadan, Houssam Shaib.Middle East respiratory syndrome coronavirus (MERS-CoV): A review.GERMS.2019)

Cat#   Antigen More
  Nucleocapsid

Expressed Host Insect
Tag His
Binding Activity  
  S1+S2 ECD

Expressed Host Insect
Tag His
Binding Activity bind DPP4
  S1 Subunit

Expressed Host Insect
Tag His
Binding Activity bind DPP4
  S1 Subunit

Expressed Host HEK293
Tag His
Binding Activity bind DPP4
  S2 Subunit

Expressed Host Insect
Tag His
Binding Activity  
  S-RBD

Expressed Host Insect
Tag mFc
Binding Activity  
  S-RBD

Expressed Host Insect
Tag His
Binding Activity  
  S-RBD

Expressed Host Insect
Tag rFc
Binding Activity bind DPP4, ACE2
  S-RBD

Expressed Host Insect
Tag rFc
Binding Activity  
  S1 Subunit(HPLC-verified)

Expressed Host HEK293
Tag His
Binding Activity  
  S1+S2 ECD (R748A, R751G, V1060P, L1061P)

Expressed Host Insect
Tag His
Binding Activity bind DPP4
Cat#   Antigen More
  NP-CoV

Ab Type Mouse MAb
Application WB, ELISA, IHC-P, FCM, ICC/IF, IP
  NP-CoV

Ab Type Rabbit PAb
Application ELISA, IHC-P, FCM, ICC/IF, IP
  NP-CoV

Ab Type Rabbit PAb
Application WB, ELISA, IHC-P, FCM, ICC/IF, IP
  NP-CoV

Ab Type Rabbit PAb
Application WB, IHC-P, ICC/IF, IP
  Spike

Ab Type Rabbit PAb
Application WB, IHC-P, ICC/IF, IP
  Spike

Ab Type Rabbit PAb
Application WB, IHC-P, ICC/IF, IP
  Spike

Ab Type Rabbit PAb
Application WB, IHC-P, ICC/IF, IP
  Spike

Ab Type Mouse MAb
Application ELISA, IHC-P, FCM, ICC/IF, IP
  Spike

Ab Type Rabbit MAb
Application Microneutralizaiton(MN)
  Spike

Ab Type Rabbit PAb
Application ELISA, IHC-P, FCM, ICC/IF, IP
  Spike

Ab Type Rabbit PAb
Application ELISA, IHC-P, FCM, ICC/IF, IP
  Spike

Ab Type Rabbit PAb
Application WB, IHC-P, IP
  Spike

Ab Type Rabbit PAb
Application WB, ELISA
  Spike

Ab Type Rabbit PAb
Application WB, ELISA, IP
  Spike

Ab Type Rabbit PAb
Application WB, ELISA, IHC-P, FCM, ICC/IF, IP
  Spike

Ab Type Mouse MAb
Application ELISA, IHC-P, FCM, ICC/IF, IP
  Spike

Ab Type Mouse MAb
Application WB, IHC-P, FCM, ICC/IF, IP
  Spike

Ab Type Rabbit PAb
Application WB, ELISA, IHC-P, IP