SARS-CoV

SARS简介

SARS是由SARS-CoV引起的严重急性呼吸道综合症。 SARS会导致严重的呼吸道疾病,例如肺炎,并伴有咳嗽(最初是干咳),发烧,发冷,疲劳,肌痛,头痛的症状。 SARS最早出现于2002年,并导致8098人被感染,病死率达9.6%。与MERS不同,自2004年以来,没有更多的病例报道。目前,尚无针对SARS-CoV-2,SARS-CoV,MERS-CoV和其他HCoVs感染的特异性疗法。对症和支持治疗是被HCoV感染的患者的主要治疗手段。

SARS-CoV

SARS-CoV属于Betacornavirus。 SARS-CoV的基因组大小从29.0 kb到30.2 kb不等,可以编码结构蛋白Spike,包膜(E),膜(M),N蛋白和非结构蛋白木瓜样蛋白酶(PLpro),胰凝乳蛋白酶样蛋白酶(3CLpro),RNA依赖的RNA聚合酶(RdRp)和解旋酶(Hel)。SARS-CoV的基因组中缺失血凝素酯酶基因。

棘突蛋白是SARS-CoV最重要的抗原分子。它由两个亚基组成; S1亚基包含一个与宿主细胞受体血管紧张素转换酶2(ACE2)结合的受体结合域(RBD),S2亚基介导病毒膜与宿主细胞膜之间的融合。在感染SARS-CoV期间,S蛋白在诱导中和抗体和T细胞反应以及保护性免疫中起关键作用。
(Ref:Hayes K.H. Luka.Molecular epidemiology, evolution and phylogeny of SARS coronavirus.Infection, Genetics and Evolution.2019)

Cat#   Antigen More
  Nucleocapsid

Expressed Host Insect
Tag His
  S1 Subunit

Expressed Host Insect
Tag His
  S-RBD

Expressed Host Insect
Tag His
  S-RBD

Expressed Host rFc
Tag His
  Plpro

Expressed Host E. coli
Tag His
  S1 Subunit (Biotinylated)

Expressed Host Insect
Tag His
  S-RBD

Expressed Host HEK293
Tag mFc
  S1 Subunit

Expressed Host HEK293
Tag mFc
Cat#   Antigen More
  Nucleocapsid

Ab Type Rabbit PAb
Application WB, ELISA, IHC-P, FCM, ICC/IF, IP
  Nucleocapsid

Ab Type Mouse MAb
Application WB, ELISA, IHC-P, FCM, ICC/IF, IP
  Nucleocapsid

Ab Type Rabbit MAb
Application WB, ELISA, IHC-P, FCM, ICC/IF, IP
  Nucleocapsid

Ab Type Rabbit PAb
Application ELISA, IHC-P, FCM, ICC/IF, IP
  Spike

Ab Type Rabbit PAb
Application WB, ELISA, IHC-P, FCM, ICC/IF, IP
  Spike

Ab Type Mouse MAb
Application ELISA, IHC-P, FCM, ICC/IF, IP
  Spike

Ab Type Rabbit PAb
Application ELISA, IHC-P, FCM, ICC/IF, IP
  Spike

Ab Type Rabbit PAb
Application WB, ELISA, FCM, IP
  Spike

Ab Type Rabbit PAb
Application WB, ELISA, IHC-P, FCM, ICC/IF, IP
  Nucleocapsid

Ab Type Rabbit MAb
Application ELISA, IHC-P, FCM, ICC/IF, IP
  Nucleocapsid

Ab Type Rabbit MAb
Application ELISA, IHC-P, FCM, ICC/IF, IP
  Nucleocapsid

Ab Type Mouse MAb
Application ELISA, IHC-P, FCM, ICC/IF, IP
  Spike

Ab Type Mouse MAb
Application ELISA, IHC-P, FCM, ICC/IF, IP
  Spike

Ab Type Mouse MAb
Application ELISA, IHC-P, FCM, ICC/IF, IP
  Spike

Ab Type Mouse MAb
Application ELISA, IHC-P, FCM, ICC/IF, IP
  Spike

Ab Type Mouse MAb
Application ELISA, IHC-P, FCM, ICC/IF, IP
  Spike

Ab Type Mouse MAb
Application ELISA, IHC-P, FCM, ICC/IF, IP
  Spike

Ab Type Mouse MAb
Application ELISA, IHC-P, FCM, ICC/IF, IP
  Spike

Ab Type Mouse MAb
Application WB, ELISA, IHC-P, FCM, ICC/IF, IP
  Spike

Ab Type Mouse MAb
Application WB, ELISA, IHC-P, FCM, ICC/IF, IP