SARS-CoV

SARS简介

SARS是由SARS-CoV引起的严重急性呼吸道综合症。 SARS会导致严重的呼吸道疾病，例如肺炎，并伴有咳嗽（最初是干咳），发烧，发冷，疲劳，肌痛，头痛的症状。 SARS最早出现于2002年，并导致8098人被感染，病死率达9.6％。与MERS不同，自2004年以来，没有更多的病例报道。目前，尚无针对SARS-CoV-2，SARS-CoV，MERS-CoV和其他HCoVs感染的特异性疗法。对症和支持治疗是被HCoV感染的患者的主要治疗手段。

SARS-CoV

SARS-CoV属于Betacornavirus。 SARS-CoV的基因组大小从29.0 kb到30.2 kb不等，可以编码结构蛋白Spike，包膜（E），膜（M），N蛋白和非结构蛋白木瓜样蛋白酶（PLpro），胰凝乳蛋白酶样蛋白酶（3CLpro），RNA依赖的RNA聚合酶（RdRp）和解旋酶（Hel）。SARS-CoV的基因组中缺失血凝素酯酶基因。

棘突蛋白是SARS-CoV最重要的抗原分子。它由两个亚基组成； S1亚基包含一个与宿主细胞受体血管紧张素转换酶2（ACE2）结合的受体结合域（RBD），S2亚基介导病毒膜与宿主细胞膜之间的融合。在感染SARS-CoV期间，S蛋白在诱导中和抗体和T细胞反应以及保护性免疫中起关键作用。
(Ref:Hayes K.H. Luka.Molecular epidemiology, evolution and phylogeny of SARS coronavirus.Infection, Genetics and Evolution.2019)

SARS-CoV 相关产品列表

SARS-CoV 蛋白
SARS-CoV 抗体

Cat#	Antigen	Expressed Host	Tag	Binding Activity
40143-V08B	Nucleocapsid	Insect	His
40634-V08B	S1+S2 ECD (577 S/A)	Insect	His	bind ACE2
40150-V08B1	S1 Subunit	Insect	His
40150-V08B1-B	S1 Subunit (Biotinylated)	Insect	His
40150-V05H1	S1 Subunit	HEK293	mFc	bind ACE2
40150-V08B2	S-RBD	Insect	His
40150-V31B2	S-RBD	Insect	rFc
40150-V05H	S-RBD	HEK293	mFc	bind ACE2
40150-V08B3	S2 subunit	Insect	His
40524-V08E	Plpro	E. coli	His
40150-V08B2-B	S-RBD (Biotinylated)	Insect	His

Cat#

Antigen

More

Nucleocapsid

S1+S2 ECD (577 S/A)

S1 Subunit

S1 Subunit (Biotinylated)

S1 Subunit

S-RBD

S-RBD

S-RBD

S2 subunit

Plpro

S-RBD (Biotinylated)

Cat#	Antigen	Ab Type	Application
40143-T62	Nucleocapsid	Rabbit PAb	WB, ELISA, IHC-P, FCM, ICC/IF, IP
40143-MM05	Nucleocapsid	Mouse MAb	WB, ELISA, IHC-P, FCM, ICC/IF, IP
40143-R001	Nucleocapsid	Rabbit MAb	WB, ELISA, IHC-P, FCM, ICC/IF, IP
40143-RP01	Nucleocapsid	Rabbit PAb	ELISA, IHC-P, FCM, ICC/IF, IP
40150-T62-COV2	Spike	Rabbit PAb	WB, ELISA, IHC-P, FCM, ICC/IF, IP
40150-MM02	Spike	Mouse MAb	ELISA, IHC-P, FCM, ICC/IF, IP
40150-RP01	Spike	Rabbit PAb	ELISA, IHC-P, FCM, ICC/IF, IP
40150-T62	Spike	Rabbit PAb	WB, ELISA, IHC-P, FCM, ICC/IF, IP
40143-R004	Nucleocapsid	Rabbit MAb	ELISA, IHC-P, FCM, ICC/IF, IP
40143-R040	Nucleocapsid	Rabbit MAb	ELISA, IHC-P, FCM, ICC/IF, IP
40143-MM08	Nucleocapsid	Mouse MAb	ELISA, IHC-P, FCM, ICC/IF, IP
40150-D004	Spike	Mouse MAb	ELISA, IHC-P, FCM, ICC/IF, IP
40150-D001	Spike	Mouse MAb	ELISA, IHC-P, FCM, ICC/IF, IP
40150-D003	Spike	Mouse MAb	ELISA, IHC-P, FCM, ICC/IF, IP
40150-D002	Spike	Mouse MAb	ELISA, IHC-P, FCM, ICC/IF, IP
40150-D005	Spike	Mouse MAb	ELISA, IHC-P, FCM, ICC/IF, IP
40150-D006	Spike	Mouse MAb	ELISA, IHC-P, FCM, ICC/IF, IP
40150-MM08	Spike	Mouse MAb	WB, ELISA, IHC-P, FCM, ICC/IF, IP
40150-MM10	Spike	Mouse MAb	WB, ELISA, IHC-P, FCM, ICC/IF, IP
40150-D001-H	Spike	Chimeric MAb	ELISA
40143-R040-H	Nucleocapsid	Rabbit MAb	ELISA