SARS-CoV

SARS简介

SARS是由SARS-CoV引起的严重急性呼吸道综合症。 SARS会导致严重的呼吸道疾病,例如肺炎,并伴有咳嗽(最初是干咳),发烧,发冷,疲劳,肌痛,头痛的症状。 SARS最早出现于2002年,并导致8098人被感染,病死率达9.6%。与MERS不同,自2004年以来,没有更多的病例报道。目前,尚无针对SARS-CoV-2,SARS-CoV,MERS-CoV和其他HCoVs感染的特异性疗法。对症和支持治疗是被HCoV感染的患者的主要治疗手段。

SARS-CoV

SARS-CoV属于Betacornavirus。 SARS-CoV的基因组大小从29.0 kb到30.2 kb不等,可以编码结构蛋白Spike,包膜(E),膜(M),N蛋白和非结构蛋白木瓜样蛋白酶(PLpro),胰凝乳蛋白酶样蛋白酶(3CLpro),RNA依赖的RNA聚合酶(RdRp)和解旋酶(Hel)。SARS-CoV的基因组中缺失血凝素酯酶基因。

棘突蛋白是SARS-CoV最重要的抗原分子。它由两个亚基组成; S1亚基包含一个与宿主细胞受体血管紧张素转换酶2(ACE2)结合的受体结合域(RBD),S2亚基介导病毒膜与宿主细胞膜之间的融合。在感染SARS-CoV期间,S蛋白在诱导中和抗体和T细胞反应以及保护性免疫中起关键作用。
(Ref:Hayes K.H. Luka.Molecular epidemiology, evolution and phylogeny of SARS coronavirus.Infection, Genetics and Evolution.2019)

Cat#   Antigen More
  Nucleocapsid

Expressed Host Insect
Tag His
  S1+S2 ECD (577 S/A)

Expressed Host Insect
Tag His
Binding Activity bind ACE2
  S1 Subunit

Expressed Host Insect
Tag His
  S1 Subunit (Biotinylated)

Expressed Host Insect
Tag His
  S1 Subunit

Expressed Host HEK293
Tag mFc
Binding Activity bind ACE2
  S-RBD

Expressed Host Insect
Tag His
  S-RBD

Expressed Host rFc
Tag His
  S-RBD

Expressed Host HEK293
Tag mFc
Binding Activity bind ACE2
  S2 subunit

Expressed Host Insect
Tag His
  Plpro

Expressed Host E. coli
Tag His
  S-RBD (Biotinylated)

Expressed Host Insect
Tag His
Cat#   Antigen More
  Nucleocapsid

Ab Type Rabbit PAb
Application WB, ELISA, IHC-P, FCM, ICC/IF, IP
  Nucleocapsid

Ab Type Mouse MAb
Application WB, ELISA, IHC-P, FCM, ICC/IF, IP
  Nucleocapsid

Ab Type Rabbit MAb
Application WB, ELISA, IHC-P, FCM, ICC/IF, IP
  Nucleocapsid

Ab Type Rabbit PAb
Application ELISA, IHC-P, FCM, ICC/IF, IP
  Spike

Ab Type Rabbit PAb
Application WB, ELISA, IHC-P, FCM, ICC/IF, IP
  Spike

Ab Type Mouse MAb
Application ELISA, IHC-P, FCM, ICC/IF, IP
40150-RP01
  Spike

Ab Type Rabbit PAb
Application ELISA, IHC-P, FCM, ICC/IF, IP
  Spike

Ab Type Rabbit PAb
Application WB, ELISA, IHC-P, FCM, ICC/IF, IP
  Nucleocapsid

Ab Type Rabbit MAb
Application ELISA, IHC-P, FCM, ICC/IF, IP
  Nucleocapsid

Ab Type Rabbit MAb
Application ELISA, IHC-P, FCM, ICC/IF, IP
  Nucleocapsid

Ab Type Mouse MAb
Application ELISA, IHC-P, FCM, ICC/IF, IP
  Spike

Ab Type Mouse MAb
Application ELISA, IHC-P, FCM, ICC/IF, IP
  Spike

Ab Type Mouse MAb
Application ELISA, IHC-P, FCM, ICC/IF, IP
  Spike

Ab Type Mouse MAb
Application ELISA, IHC-P, FCM, ICC/IF, IP
  Spike

Ab Type Mouse MAb
Application ELISA, IHC-P, FCM, ICC/IF, IP
  Spike

Ab Type Mouse MAb
Application ELISA, IHC-P, FCM, ICC/IF, IP
  Spike

Ab Type Mouse MAb
Application ELISA, IHC-P, FCM, ICC/IF, IP
  Spike

Ab Type Mouse MAb
Application WB, ELISA, IHC-P, FCM, ICC/IF, IP
  Spike

Ab Type Mouse MAb
Application WB, ELISA, IHC-P, FCM, ICC/IF, IP
  Spike

Ab Type Chimeric MAb
Application ELISA
  Nucleocapsid

Ab Type Rabbit MAb
Application ELISA
Recombinant Antibody Production