AACS Protein Overview: Sequence, Structure, Function and Protein Interaction

AACS Protein Overview

AACS reagents

AACS (EC is a cytosolic ligase that specifically activates the ketone body acetoacetate to form acetoacetyl-coenzyme A (CoA) for the synthesis of cholesterol and fatty acids (Ohgami et al., 2003).

AACS protein family

Belongs to the ATP-dependent AMP-binding enzyme family.

AACS protein name

Recommended name
Acetoacetyl-CoA synthetase
ACSF1, acyl-CoA synthetase family member 1, FLJ12389, SUR-5
Alternative name
Acyl-CoA synthetase family member 1 Protein sur-5 homolog

AACS Gene family protein

Acyl-CoA synthetase family
Approved symbol Common name
SLC27A4 SLC27A4/FATP4 protein, recombinant

AACS Protein Sequence

Species Human AACS protein
Length 672
Mass (Da) 75144
Sequence Human AACS protein sequence
Species Mouse AACS protein
Length 672
Mass (Da) 75200
Sequence Mouse AACS protein sequence
Species Rat AACS protein
Length 672
Mass (Da) 75040
Sequence Rat AACS protein sequence

AACS Protein Molecular Weight & PI

Acetoacetyl-CoA synthetase (EC (Acyl-CoA synthetase family member 1) (Protein sur-5 homolog)Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 1-672 Acetoacetyl-CoA synthetase.

Molecular weight (Da)


Theoretical pI


AACS Protein Interaction

Recombinant AACS Protein Feature

AACS Protein, Human, Recombinant (His Tag)

High Purity
> 96 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method

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