ABCB5 Information: ABCB5 Protein, ABCB5 Antibody and ABCB5 Gene

ABCB5 Gene family

ABCB5 Protein

ABCB5 protein function

Drug efflux transporter present in a number of stem cells that acts as a regulator of cellular differentiation. Able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Specifically present in limbal stem cells, where it plays a key role in corneal development and repair. {ECO:0000269|PubMed:12960149, ECO:0000269|PubMed:15205344, ECO:0000269|PubMed:15899824, ECO:0000269|PubMed:22306008}.

ABCB5 protein expression

Tissue specificity

Expressed by CD133-expressing progenitor cells among epidermal melanocytes (at protein level). Widely expressed with specific expression in pigment cells. Highly expressed in several malignant tissues: highly expressed in clinical melanomas, with low expression in normal skin. In melanoma, marks malignant melanoma-initiating cells (MMIC), in which clinical virulence resides as a consequence of unlimited self-renewal capacity, resulting in inexorable tumor progression and metastasis. Also highly expressed in a number of leukemia cells. Expressed in basal limbal epithelium.

ABCB5 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
  • Mass (KDa)

ABCB5 Antibody

There are 1 ABCB5 antibodies which are validated in multiple tissues with various applications, including WB. There are 1 ABCB5 antibody for WB. Among all these ABCB5 antibodies, there are 1 anti-ABCB5 rabbit polyclonal antibodies . All the ABCB5 anbodies are produced in house and all are in stock. ABCB5 antibody customerized service is available.

ABCB5 Gene

ABCB5 cDNA / gene is a protein coding gene.The ABCB5 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, M.oryzae, A.thaliana, and frog.144 organisms have orthologs with human gene ABCB5