ABCG1 Information: ABCG1 Protein, ABCG1 Antibody and ABCG1 Gene

ABCG1 Gene family

ABCG1 Protein

ABCG1 protein function

Transporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages.

ABCG1 protein expression

Tissue specificity

Expressed in several tissues. Expressed in macrophages; expression is increased in macrophages from patients with Tangier disease.

Induction

Strongly induced in monocyte-derived macrophages during cholesterol influx. Conversely, mRNA and protein expression are suppressed by lipid efflux. Induction is mediated by the liver X receptor/retinoid X receptor (LXR/RXR) pathway. Not induced by bacterial lipopolysaccharides (LPS). Repressed by ZNF202.

ABCG1 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    678.00
  • Mass (KDa)
    75.00

ABCG1 Gene

ABCG1 cDNA / gene is a gene with protein product which located on 21q22.3. The ABCG1 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, C.elegans, A.thaliana, rice, and frog. 199 organisms have orthologs with human gene ABCG1.