ABCG8 Information: ABCG8 Protein, ABCG8 Antibody and ABCG8 Gene

ABCG8 Gene family

ABCG8 Protein

ABCG8 protein function

ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane. Plays an essential role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile (PubMed:11099417, PubMed:11452359, PubMed:27144356, PubMed:15054092). Required for normal sterol homeostasis (PubMed:11099417, PubMed:11452359, PubMed:15054092). The heterodimer with ABCG5 has ATPase activity (PubMed:16893193, PubMed:20210363, PubMed:27144356).

ABCG8 protein expression

Tissue specificity

Predominantly expressed in the liver (PubMed:11099417, PubMed:11452359). Low expression levels in the small intestine and colon (PubMed:11099417). Very low levels in other tissues, including brain, heart and spleen (PubMed:11452359).

ABCG8 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
  • Mass (KDa)

ABCG8 Gene

ABCG8 cDNA / gene is a gene with protein product which located on 2p21. The ABCG8 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, S.cerevisiae, K.lactis, M.oryzae, A.thaliana, rice, and frog. 243 organisms have orthologs with human gene ABCG8.