GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration.
ACAP1/CENTB1 protein expression
Highest level in lung and spleen. Low level in heart, kidney, liver and pancreas.
ACAP1 cDNA / gene is a gene with protein product which located on 17p13.1. The ACAP1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and zebrafish. 155 organisms have orthologs with human gene ACAP1.