ACE2 Information: ACE2 Protein, ACE2 Antibody and ACE2 Gene

ACE2 Protein

ACE2 protein function

Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. {ECO:0000269|PubMed:10924499, ECO:0000269|PubMed:10969042, ECO:0000269|PubMed:14647384, ECO:0000269|PubMed:24227843}.; (Microbial infection) Acts as a receptor for SARS coronavirus/SARS-CoV. {ECO:0000269|PubMed:14647384, ECO:0000269|PubMed:15452268, ECO:0000269|PubMed:15791205}.; (Microbial infection) Acts as a receptor for Human coronavirus NL63/HCoV-NL63. {ECO:0000269|PubMed:15897467}.

ACE2 protein expression

Tissue specificity

Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells (at protein level). Expressed in heart, kidney, testis, and gastrointestinal system.

Induction

Up-regulated in failing heart.

ACE2 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    805.00
  • Mass (KDa)
    92.00

ACE2 Antibody

There are 15 ACE2 antibodies which are validated in multiple tissues with various applications, including ELISA, IHC-P, FCM, Neutralization, WB, IP, ELISA(Cap), ELISA(Det). There are 9 ACE2 antibody for ELISA, 5 ACE2 antibody for IHC-P, 6 ACE2 antibody for FCM, 2 ACE2 antibody for Neutralization, 1 ACE2 antibody for WB, 1 ACE2 antibody for IP, 1 ACE2 antibody for ELISA(Cap), 1 ACE2 antibody for ELISA(Det). Among all these ACE2 antibodies, there are 7 anti-ACE2 mouse monoclonal antibodies , 4 anti-ACE2 rabbit monoclonal antibodies , 4 anti-ACE2 rabbit polyclonal antibodies . All the ACE2 anbodies are produced in house and all are in stock. ACE2 antibody customerized service is available.

ACE2 Gene

ACE2 gene / cDNA is a protein-coding gene which located on Xp22.2. The ACE2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, C.elegans, and frog.236 organisms have orthologs with human gene ACE2.