ACIN1 Information: ACIN1 Protein, ACIN1 Antibody and ACIN1 Gene

ACIN1 Gene family

ACIN1 Protein

ACIN1 protein function

Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells.

ACIN1 protein expression

Tissue specificity

Ubiquitous. The Ser-1180 phosphorylated form (by SRPK2) is highly expressed and phosphorylated in patients with myeloid hematologic malignancies.

ACIN1 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
  • Mass (KDa)

ACIN1 Antibody

There are 1 ACIN1 antibodies which are validated in multiple tissues with various applications, including IHC-P. There are 1 ACIN1 antibody for IHC-P. Among all these ACIN1 antibodies, there are 1 anti-ACIN1 rabbit polyclonal antibodies . All the ACIN1 anbodies are produced in house and all are in stock. ACIN1 antibody customerized service is available.

ACIN1 Gene

ACIN1 cDNA / gene is a gene with protein product which located on 14q11.2. The ACIN1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, and frog. 147 organisms have orthologs with human gene ACIN1.