ACMSD Information: ACMSD Protein, ACMSD Antibody and ACMSD Gene

ACMSD Protein

ACMSD protein function

Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.

ACMSD protein sequence

This sequence information is just for reference only.From Uniport

  • Length
  • Mass (KDa)


ACMSD cDNA / gene is a gene with protein product which located on 2q21.3. The ACMSD gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, C.elegans, M.oryzae, N.crassa, and frog. 247 organisms have orthologs with human gene ACMSD.