Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (By similarity). Succinyl-CoA thioesterase that also hydrolyzes long chain saturated and unsaturated monocarboxylic acyl-CoAs.
ACOT4 protein expression
Strongest expression in liver and kidney and weaker expression in placenta, heart, and muscle.
ACOT4 cDNA / gene is a gene with protein product which located on 14q24.3. The ACOT4 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat. 54 organisms have orthologs with human gene ACOT4.