ACOT8 Information: ACOT8 Protein, ACOT8 Antibody and ACOT8 Gene

ACOT8 Gene family

ACOT8 Protein

ACOT8 protein function

Acyl-coenzyme A (acyl-CoA) thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:9299485, PubMed:9153233, PubMed:15194431). Competes with bile acid CoA:amino acid N-acyltransferase (BAAT) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). Shows a preference for medium-length fatty acyl-CoAs (C2 to C20) (PubMed:9299485, PubMed:9153233). Inactive towards substrates with more than C20 aliphatic chains (PubMed:9153233). Involved in the metabolic regulation of peroxisome proliferation (PubMed:15194431).

ACOT8 protein expression

Tissue specificity

Detected in a T-cell line (at protein level). Ubiquitous (PubMed:9153233, PubMed:9299485).


Regulated by peroxisome proliferator (such as Clofibrate), via the peroxisome proliferator-activated receptors (PPARs).

ACOT8 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
  • Mass (KDa)

ACOT8 Gene

ACOT8 cDNA / gene is a gene with protein product which located on 20q13.12. The ACOT8 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, C.elegans, A.thaliana, and frog. 233 organisms have orthologs with human gene ACOT8.