Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro) (By similarity).
ACSM5 cDNA / gene is a gene with protein product which located on 16p12.3. The ACSM5 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and chicken. 91 organisms have orthologs with human gene ACSM5.