ACVR2B Information: ACVR2B Protein, ACVR2B Antibody and ACVR2B Gene

ACVR2B Gene family

ACVR2B Protein

ACVR2B protein function

Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. {ECO:0000269|PubMed:8622651}.

ACVR2B protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    512.00
  • Mass (KDa)
    57.00

ACVR2B Antibody

There are 7 ACVR2B antibodies which are validated in multiple tissues with various applications, including ELISA, WB. There are 7 ACVR2B antibody for ELISA, 1 ACVR2B antibody for WB. Among all these ACVR2B antibodies, there are 3 anti-ACVR2B rabbit monoclonal antibodies , 4 anti-ACVR2B rabbit polyclonal antibodies . All the ACVR2B anbodies are produced in house and all are in stock. ACVR2B antibody customerized service is available.

ACVR2B Gene

ACVR2B gene / cDNA is a protein-coding gene which located on 3p22.2. The ACVR2B gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.216 organisms have orthologs with human gene ACVR2B.