ACVR2B Gene Sequence, Family, Fuction and Expression Information
ACVR2B cDNA / Gene Overview
ACVR2B gene / cDNA is a protein-coding gene which located on 3p22.2. The ACVR2B gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.216 organisms have orthologs with human gene ACVR2B.
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq, Jul 2008]
ACVR2B cDNA / Gene Sequence
LOCUS NM_001106 11373 bp mRNA linear PRI 23-JUN-2018
Homo sapiens activin A receptor type 2B (ACVR2B), mRNA.
This sequence information is just for reference only.