ADAM10 Information: ADAM10 Protein, ADAM10 Antibody and ADAM10 Gene

ADAM10 Gene family

ADAM10 Protein

ADAM10 protein function

Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) (PubMed:26686862, PubMed:11786905, PubMed:29224781). Contributes to the normal cleavage of the cellular prion protein (PubMed:11477090). Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity (PubMed:12475894). Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis (By similarity). Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form (PubMed:17557115). Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B (PubMed:19114711, PubMed:21288900). May regulate the EFNA5-EPHA3 signaling (PubMed:16239146). {ECO:0000250|UniProtKB:O35598, ECO:0000269|PubMed:11477090, ECO:0000269|PubMed:11786905, ECO:0000269|PubMed:12475894, ECO:0000269|PubMed:16239146, ECO:0000269|PubMed:17557115, ECO:0000269|PubMed:19114711, ECO:0000269|PubMed:20592283, ECO:0000269|PubMed:21288900, ECO:0000269|PubMed:26686862, ECO:0000269|PubMed:29224781}.

ADAM10 protein expression

Tissue specificity

Expressed in spleen, lymph node, thymus, peripheral blood leukocyte, bone marrow, cartilage, chondrocytes and fetal liver.

Induction

In osteoarthritis affected-cartilage.

ADAM10 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    748.00
  • Mass (KDa)
    84.00

ADAM10 Antibody

There are 5 ADAM10 antibodies which are validated in multiple tissues with various applications, including WB, IHC-P, ICC/IF. There are 3 ADAM10 antibody for WB, 2 ADAM10 antibody for IHC-P, 1 ADAM10 antibody for ICC/IF. Among all these ADAM10 antibodies, there are 5 anti-ADAM10 rabbit polyclonal antibodies . All the ADAM10 anbodies are produced in house and all are in stock. ADAM10 antibody customerized service is available.

ADAM10 Gene

ADAM10 gene / cDNA is a protein-coding gene which located on 15q21.3. The ADAM10 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, mosquito, and frog.232 organisms have orthologs with human gene ADAM10.