ADAM15 Information: ADAM15 Protein, ADAM15 Antibody and ADAM15 Gene

ADAM15 Gene family

ADAM15 Protein

ADAM15 protein function

Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain. {ECO:0000269|PubMed:12091380, ECO:0000269|PubMed:15358598, ECO:0000269|PubMed:15818704, ECO:0000269|PubMed:17416588, ECO:0000269|PubMed:17575078, ECO:0000269|PubMed:18387333, ECO:0000269|PubMed:18434311}.

ADAM15 protein expression

Tissue specificity

Expressed in colon and small intestine. Expressed in airway smooth muscle and glomerular mesangial cells (at protein level). Ubiquitously expressed. Overexpressed in atherosclerotic lesions. Constitutively expressed in cultured endothelium and smooth muscle. Expressed in chondrocytes. Expressed in airway smooth muscle and glomerular mesangial cells.

ADAM15 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
  • Mass (KDa)

ADAM15 Antibody

There are 15 ADAM15 antibodies which are validated in multiple tissues with various applications, including ELISA, FCM, ELISA(Det), IHC-P, ICC/IF, ELISA(Cap). There are 7 ADAM15 antibody for ELISA, 7 ADAM15 antibody for FCM, 1 ADAM15 antibody for ELISA(Det), 3 ADAM15 antibody for IHC-P, 2 ADAM15 antibody for ICC/IF, 1 ADAM15 antibody for ELISA(Cap). Among all these ADAM15 antibodies, there are 4 anti-ADAM15 mouse monoclonal antibodies , 5 anti-ADAM15 rabbit monoclonal antibodies , 6 anti-ADAM15 rabbit polyclonal antibodies . All the ADAM15 anbodies are produced in house and all are in stock. ADAM15 antibody customerized service is available.

ADAM15 Gene

ADAM15 gene / cDNA is a protein-coding gene which located on 1q21.3. The ADAM15 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and zebrafish.174 organisms have orthologs with human gene ADAM15.