ADAM17 Information: ADAM17 Protein, ADAM17 Antibody and ADAM17 Gene

ADAM17 Gene family

ADAM17 Protein

ADAM17 protein function

Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2. {ECO:0000269|PubMed:12441351, ECO:0000269|PubMed:20592283, ECO:0000269|PubMed:24226769, ECO:0000269|PubMed:24227843}.

ADAM17 protein expression

Tissue specificity

Ubiquitously expressed. Expressed at highest levels in adult heart, placenta, skeletal muscle, pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney.

Induction

In arthritis-affected cartilage.

ADAM17 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    824.00
  • Mass (KDa)
    93.00

ADAM17 Antibody

There are 4 ADAM17 antibodies which are validated in multiple tissues with various applications, including IP, WB, ICC/IF, IHC-P, ELISA. There are 1 ADAM17 antibody for IP, 1 ADAM17 antibody for WB, 1 ADAM17 antibody for ICC/IF, 1 ADAM17 antibody for IHC-P, 1 ADAM17 antibody for ELISA. Among all these ADAM17 antibodies, there are 4 anti-ADAM17 rabbit polyclonal antibodies . All the ADAM17 anbodies are produced in house and all are in stock. ADAM17 antibody customerized service is available.

ADAM17 Gene

ADAM17 gene / cDNA is a protein-coding gene which located on 2p25.1. The ADAM17 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, and frog.218 organisms have orthologs with human gene ADAM17.