Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein.
ADAM2 protein expression
Expressed specifically in spermatogenic cells in the seminiferous cells. Not detected in fetal tissues.
ADAM2 cDNA / gene is a gene with protein product which located on 8p11.22. The ADAM2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat. 88 organisms have orthologs with human gene ADAM2.