May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in sperm maturation.
ADAM28 protein expression
Expressed predominantly in secondary lymphoid tissues, such as lymph node, spleen, small intestine, stomach, colon, appendix and trachea. The lymphocyte population is responsible for expression of this protein in these tissues. Isoform 2 is expressed preferentially in spleen.
ADAM28 cDNA / gene is a gene with protein product which located on 8p21.2. The ADAM28 gene is conserved in Rhesus monkey, dog, cow, mouse, rat, chicken, and frog. 155 organisms have orthologs with human gene ADAM28.