Cleaves aggrecan, a cartilage proteoglycan, at the '1938-Glu-|-Leu-1939' site (within the chondroitin sulfate attachment domain), and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture.
ADAMTS1 protein sequence
This sequence information is just for reference only.From Uniport
ADAMTS1 cDNA / gene is a gene with protein product which located on 21q21.3. The ADAMTS1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. 241 organisms have orthologs with human gene ADAMTS1.