ADAMTS12 Information: ADAMTS12 Protein, ADAMTS12 Antibody and ADAMTS12 Gene

ADAMTS12 Gene family

ADAMTS12 Protein

ADAMTS12 protein function

Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties.

ADAMTS12 protein expression

Tissue specificity

Expressed in skeletal muscle and fat. Detected at significant levels in fetal lung. Widely expressed in gastric carcinomas and in cancer cells of diverse origin.

Induction

By IFN-alpha and by IL1B/interleukin-1 beta. Up-regulated in articular cartilage and synovium from arthritis patients. Up-regulared in chondrocytes.

ADAMTS12 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    1,594.00
  • Mass (KDa)
    177.00

ADAMTS12 Gene

ADAMTS12 cDNA / gene is a gene with protein product which located on 5p13.3-p13.2. The ADAMTS12 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. 186 organisms have orthologs with human gene ADAMTS12.