May play a role in tissue-remodeling process occurring in both normal and pathological conditions. May have a protease-independent function in the transport from the endoplasmic reticulum to the Golgi apparatus of secretory cargos, mediated by the GON domain.
ADAMTS20 protein expression
Very sparingly expressed, although is detected at low levels in testis, prostate, ovary, heart, placenta, lung and pancreas. Overexpressed in several brain, colon and breast carcinomas.
ADAMTS20 cDNA / gene is a gene with protein product which located on 12q12. The ADAMTS20 gene is conserved in Rhesus monkey, dog, cow, mouse, rat, chicken, and frog. 190 organisms have orthologs with human gene ADAMTS20.