ADAMTS4 Information: ADAMTS4 Protein, ADAMTS4 Antibody and ADAMTS4 Gene

ADAMTS4 Gene family

ADAMTS4 Protein

ADAMTS4 protein function

Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.

ADAMTS4 protein expression

Tissue specificity

Expressed in brain, lung and heart (PubMed:23897278). Expressed at very low level in placenta and skeletal muscles (PubMed:23897278). Isoform 2: Detected in osteoarthritic synovium (PubMed:16723216, PubMed:23897278).

Induction

By IL1/interleukin-1.

ADAMTS4 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    837.00
  • Mass (KDa)
    90.00

ADAMTS4 Antibody

There are 1 ADAMTS4 antibodies which are validated in multiple tissues with various applications, including IHC-P. There are 1 ADAMTS4 antibody for IHC-P. Among all these ADAMTS4 antibodies, there are 1 anti-ADAMTS4 rabbit polyclonal antibodies . All the ADAMTS4 anbodies are produced in house and all are in stock. ADAMTS4 antibody customerized service is available.

ADAMTS4 Gene

ADAMTS4 gene / cDNA is a protein-coding gene which located on 1q23.3. The ADAMTS4 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and frog.142 organisms have orthologs with human gene ADAMTS4.