ADAMTS5 Information: ADAMTS5 Protein, ADAMTS5 Antibody and ADAMTS5 Gene

ADAMTS5 Gene family

ADAMTS5 Protein

ADAMTS5 protein function

Metalloproteinase that plays an important role in connective tissue organization, development, inflammation, arthritis, and cell migration. ADAMTS5 is an extracellular matrix (ECM) degrading enzyme that show proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) including aggrecan, versican, brevican and neurocan (PubMed:16133547, PubMed:18992360). Cleavage within the hyalectans occurs at Glu-Xaa recognition motifs. Plays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle development through its versican remodeling properties. Participates in development of brown adipose tissue and browning of white adipose tissue. Plays an important role for T-lymphocyte migration from draining lymph nodes following viral infection.

ADAMTS5 protein expression

Tissue specificity

Expressed at low level in placenta primarily but also detected in heart and brain, cervix, uterus, bladder, esophagus, rib cartilage, chondroblastoma, fibrous tissue and a joint capsule from an arthritic patient.

ADAMTS5 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    930.00
  • Mass (KDa)
    101.00

ADAMTS5 Gene

ADAMTS5 cDNA / gene is a gene with protein product which located on 21q21.3. The ADAMTS5 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. 243 organisms have orthologs with human gene ADAMTS5.