Adducin 2/ADD2 Information: Adducin 2/ADD2 Protein, Adducin 2/ADD2 Antibody and Adducin 2/ADD2 Gene

Adducin 2/ADD2 Protein

Adducin 2/ADD2 protein function

Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit.

Adducin 2/ADD2 protein expression

Tissue specificity

Expressed mainly in brain, spleen, kidney cortex and medulla, and heart. Also expressed in human umbilical vein endothelial cells, human vascular smooth muscle cells, kidney tubular cells and K-562 cell line.


Fetal kidney expresses isoforms 3, 4, 5, 6 and 7, and fetal liver expresses isoforms 3 and 4.

Adducin 2/ADD2 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
  • Mass (KDa)

Adducin 2/ADD2 Gene

ADD2 cDNA / gene is a gene with protein product which located on 2p13.3. The ADD2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, and frog. 192 organisms have orthologs with human gene ADD2.