Adenosine Deaminase Information: Adenosine Deaminase Protein, Adenosine Deaminase Antibody and Adenosine Deaminase Gene

Adenosine Deaminase Gene family

Adenosine Deaminase Protein

Adenosine Deaminase protein function

Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine (PubMed:8452534, PubMed:16670267). Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4 (PubMed:20959412). Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion (PubMed:11772392). Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion (By similarity). Enhances CD4+ T-cell differentiation and proliferation (PubMed:20959412). Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change (PubMed:23193172). Stimulates plasminogen activation (PubMed:15016824). Plays a role in male fertility (PubMed:21919946, PubMed:26166670). Plays a protective role in early postimplantation embryonic development (By similarity). {ECO:0000250|UniProtKB:P03958, ECO:0000250|UniProtKB:P56658, ECO:0000269|PubMed:11772392, ECO:0000269|PubMed:15016824, ECO:0000269|PubMed:16670267, ECO:0000269|PubMed:20959412, ECO:0000269|PubMed:21919946, ECO:0000269|PubMed:23193172, ECO:0000269|PubMed:26166670, ECO:0000269|PubMed:8452534}.

Adenosine Deaminase protein expression

Tissue specificity

Found in all tissues, occurs in large amounts in T-lymphocytes (PubMed:20959412). Expressed at the time of weaning in gastrointestinal tissues.

Induction

Up-regulated by hypoxia.

Adenosine Deaminase protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    363.00
  • Mass (KDa)
    40.00

Adenosine Deaminase Antibody

There are 5 Adenosine Deaminase antibodies which are validated in multiple tissues with various applications, including WB, ICC/IF, IP, IHC-P, ELISA. There are 4 Adenosine Deaminase antibody for WB, 1 Adenosine Deaminase antibody for ICC/IF, 4 Adenosine Deaminase antibody for IP, 1 Adenosine Deaminase antibody for IHC-P, 2 Adenosine Deaminase antibody for ELISA. Among all these Adenosine Deaminase antibodies, there are 4 anti-Adenosine Deaminase rabbit polyclonal antibodies , 1 anti-Adenosine Deaminase mouse monoclonal antibodies . All the Adenosine Deaminase anbodies are produced in house and all are in stock. Adenosine Deaminase antibody customerized service is available.

Adenosine Deaminase Gene

ADA gene / cDNA is a protein-coding gene which located on 20q13.12. The ADA gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, C.elegans, S.cerevisiae, K.lactis, S.pombe, and frog.234 organisms have orthologs with human gene ADA.