ADGRA2 Information: ADGRA2 Protein, ADGRA2 Antibody and ADGRA2 Gene

ADGRA2 Gene family

ADGRA2 Protein

ADGRA2 protein function

Endothelial receptor which functions as a WNT7-specific coactivator of canonical Wnt signaling (By similarity). Required for normal endothelial cell sprouting and migration in the forebrain and neural tube (By similarity). Has a major role in establishing the blood-brain barrier (By similarity). Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate (PubMed:16982628).

ADGRA2 protein expression

Tissue specificity

Expressed in endothelial cells (at protein level) (PubMed:15021905, PubMed:16982628). Abundantly expressed in heart, placenta, ovary, small intestine, and colon (PubMed:15021905).

ADGRA2 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    1,338.00
  • Mass (KDa)
    142.00

ADGRA2 Gene

ADGRA2 cDNA / gene is a gene with protein product which located on 8p11.23. The ADGRA2 gene is conserved in chimpanzee, Rhesus monkey, dog, mouse, rat, chicken, zebrafish, and frog. 208 organisms have orthologs with human gene ADGRA2.