ADGRB1 Information: ADGRB1 Protein, ADGRB1 Antibody and ADGRB1 Gene

ADGRB1 Gene family

ADGRB1 Protein

ADGRB1 protein function

Phosphatidylserine receptor which enhances the engulfment of apoptotic cells (PubMed:24509909). Also mediates the binding and engulfment of Gram-negative bacteria (PubMed:26838550). Stimulates production of reactive oxygen species by macrophages in response to Gram-negative bacteria, resulting in enhanced microbicidal macrophage activity (PubMed:26838550). In the gastric mucosa, required for recognition and engulfment of apoptotic gastric epithelial cells (PubMed:24509909). Promotes myoblast fusion (By similarity). Activates the Rho pathway in a G-protein-dependent manner (PubMed:23782696). Inhibits MDM2-mediated ubiquitination and degradation of DLG4/PSD95, promoting DLG4 stability and regulating synaptic plasticity (By similarity). Required for the formation of dendritic spines by ensuring the correct localization of PARD3 and TIAM1 (By similarity). Potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53/TP53 signal in suppression of glioblastoma (PubMed:11875720).

ADGRB1 protein expression

Tissue specificity

Expressed in brain (at protein level) (PubMed:12074842, PubMed:12507886). Expressed on mononuclear phagocytes and monocyte-derived macrophages in the gastric mucosa (at protein level) (PubMed:24509909). Expressed in normal pancreatic tissue but not in pancreatic tumor tissue (PubMed:11875720). Reduced or no expression is observed in some glioblastomas (PubMed:12507886).

Induction

By p53/TP53.

ADGRB1 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    1,584.00
  • Mass (KDa)
    173.00

ADGRB1 Antibody

There are 1 ADGRB1 antibodies which are validated in multiple tissues with various applications, including IHC-P. There are 1 ADGRB1 antibody for IHC-P. Among all these ADGRB1 antibodies, there are 1 anti-ADGRB1 rabbit polyclonal antibodies . All the ADGRB1 anbodies are produced in house and all are in stock. ADGRB1 antibody customerized service is available.

ADGRB1 Gene

ADGRB1 cDNA / gene is a gene with protein product which located on 8q24.3. The ADGRB1 gene is conserved in Rhesus monkey, dog, cow, mouse, rat, chicken, and frog. 174 organisms have orthologs with human gene ADGRB1.