Orphan G-protein coupled receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT-signaling pathway, a transcription factor, via the G-protein GNAZ (PubMed:20367554, PubMed:28891236). Involved in angiogenesis inhibition (By similarity).
ADGRB2 protein expression
Strongly expressed in brain. Also detected in heart, thymus, skeletal muscle, and different cell lines.
ADGRB2 cDNA / gene is a gene with protein product which located on 1p35.2. The ADGRB2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog. 196 organisms have orthologs with human gene ADGRB2.