Receptor that plays a role in the regulation of synaptogenesis and dendritic spine formation at least partly via interaction with ELMO1 and RAC1 activity (By similarity). Promotes myoblast fusion through ELMO/DOCK1 (PubMed:24567399).
ADGRB3 protein expression
Strongly expressed in brain. Also detected in heart. Reduced expression in some glioblastoma cell lines.
ADGRB3 cDNA / gene is a gene with protein product which located on 6q12-q13. The ADGRB3 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. 205 organisms have orthologs with human gene ADGRB3.