Orphan receptor that regulates migration of lymphatic endothelial cells in vitro via the small GTPases RhoA and CDC42 (PubMed:24178298). Regulates B-cell development (By similarity). Seems to signal through G-alpha(q)-proteins (PubMed:22575658).
ADGRG3 protein expression
Expressed in cultured primary dermal lymphatic endothelial cells.
ADGRG3 cDNA / gene is a gene with protein product which located on 16q21. The ADGRG3 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and zebrafish. 167 organisms have orthologs with human gene ADGRG3.