Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis.
Aen protein expression
Up-regulated by p53/TP53 in response to ionizing radiation and DNA-damaging agents such as adriamycin. Phosphorylation of p53/TP53 at 'Ser-15' is required for effective induction.
Aen protein sequence
This sequence information is just for reference only.From Uniport
AEN cDNA / gene is a gene with protein product which located on 15q26.1. The AEN gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, and frog. 150 organisms have orthologs with human gene AEN.