AFF4 Information: AFF4 Protein, AFF4 Antibody and AFF4 Gene

AFF4 Gene family

AFF4 Protein

AFF4 protein function

Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression.

AFF4 protein expression

Tissue specificity

Ubiquitously expressed. Strongly expressed in heart, placenta, skeletal muscle, pancreas and to a lower extent in brain.

Induction

Expressed in fetal heart, lung, brain and to a lower extent liver.

AFF4 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    1,163.00
  • Mass (KDa)
    127.00

AFF4 Antibody

There are 1 AFF4 antibodies which are validated in multiple tissues with various applications, including WB, IHC-P, ICC/IF. There are 1 AFF4 antibody for WB, 1 AFF4 antibody for IHC-P, 1 AFF4 antibody for ICC/IF. Among all these AFF4 antibodies, there are 1 anti-AFF4 rabbit polyclonal antibodies . All the AFF4 anbodies are produced in house and all are in stock. AFF4 antibody customerized service is available.

AFF4 Gene

AFF4 cDNA / gene is a gene with protein product which located on 5q31.1. The AFF4 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, and frog. 238 organisms have orthologs with human gene AFF4.