AFG3L2 Information: AFG3L2 Protein, AFG3L2 Antibody and AFG3L2 Gene

AFG3L2 Gene family

AFG3L2 Protein

AFG3L2 protein function

ATP-dependent protease which is essential for axonal and neuron development. In neurons, mediates degradation of SMDT1/EMRE before its assembly with the uniporter complex, limiting the availability of SMDT1/EMRE for MCU assembly and promoting efficient assembly of gatekeeper subunits with MCU (PubMed:27642048). Required for the maturation of paraplegin (SPG7) after its cleavage by mitochondrial-processing peptidase (MPP), converting it into a proteolytically active mature form (By similarity).

AFG3L2 protein expression

Tissue specificity

Ubiquitous. Highly expressed in the cerebellar Purkinje cells.

AFG3L2 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    797.00
  • Mass (KDa)
    88.00

AFG3L2 Antibody

There are 1 AFG3L2 antibodies which are validated in multiple tissues with various applications, including WB, IHC-P, ICC/IF, IP. There are 1 AFG3L2 antibody for WB, 1 AFG3L2 antibody for IHC-P, 1 AFG3L2 antibody for ICC/IF, 1 AFG3L2 antibody for IP. Among all these AFG3L2 antibodies, there are 1 anti-AFG3L2 rabbit polyclonal antibodies . All the AFG3L2 anbodies are produced in house and all are in stock. AFG3L2 antibody customerized service is available.

AFG3L2 Gene

AFG3L2 cDNA / gene is a gene with protein product which located on 18p11.21. The AFG3L2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, E.gossypii, A.thaliana, rice, and frog. 233 organisms have orthologs with human gene AFG3L2.