Acylglycerol Kinase/AGK Information: Acylglycerol Kinase/AGK Protein, Acylglycerol Kinase/AGK Antibody and Acylglycerol Kinase/AGK Gene

Acylglycerol Kinase/AGK Protein

Acylglycerol Kinase/AGK protein function

Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively (PubMed:15939762). Does not phosphorylate sphingosine (PubMed:15939762). Independently of its lipid kinase activity, acts as a component of the TIM22 complex (PubMed:28712724, PubMed:28712726). The TIM22 complex mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane by forming a twin-pore translocase that uses the membrane potential as the external driving force (PubMed:28712724, PubMed:28712726). In the TIM22 complex, required for the import of a subset of metabolite carriers into mitochtondria, such as ANT1/SLC25A4 and SLC25A24, while it is not required for the import of TIMM23 (PubMed:28712724). Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth (PubMed:15939762).

Acylglycerol Kinase/AGK protein expression

Tissue specificity

Highly expressed in muscle, heart, kidney and brain.

Induction

Overexpressed in prostate cancer, suggesting that it may play a role in initiation and progression of prostate cancer, processes in which lysophosphatidic acid (LPA) plays key roles.

Acylglycerol Kinase/AGK protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    422.00
  • Mass (KDa)
    47.00

Acylglycerol Kinase/AGK Gene

AGK cDNA / gene is a gene with protein product which located on 7q34. The AGK gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, and frog. 237 organisms have orthologs with human gene AGK.