AGR3 Information: AGR3 Protein, AGR3 Antibody and AGR3 Gene

AGR3 Gene family

AGR3 Protein

AGR3 protein function

Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in tracheal epithelial cells. {ECO:0000250|UniProtKB:Q8R3W7}.

AGR3 protein expression

Tissue specificity

Expressed in the lung, in the ciliated cells of the airway epithelium (PubMed:25751668). Expression increased with differentiation of airway epithelial cells (PubMed:25751668). Not detected in the mucous cells (PubMed:25751668). Expressed in ciliated cells in the oviduct (PubMed:26170690). Also detected in stomach, colon, prostate and liver (PubMed:25751668). Expressed in breast, ovary, prostate and liver cancer (PubMed:26170690). Expression is associated with the level of differentiation of breast cancer (at protein level) (PubMed:26170690).

Induction

Not induced as part of the cellular response to endoplasmic reticulum stress (PubMed:25751668). Up-regulated by androgens and by estrogens in prostate cancer cells (PubMed:23294566) Up-regulated by a hormone (estrogen-receptor alpha) independent mechanism in ovarian cancer (PubMed:22361111).

AGR3 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    166.00
  • Mass (KDa)
    19.00

AGR3 Antibody

There are 1 AGR3 antibodies which are validated in multiple tissues with various applications, including ICC/IF. There are 1 AGR3 antibody for ICC/IF. Among all these AGR3 antibodies, there are 1 anti-AGR3 rabbit polyclonal antibodies . All the AGR3 anbodies are produced in house and all are in stock. AGR3 antibody customerized service is available.

AGR3 Gene

AGR3 gene / cDNA is a protein-coding gene which located on 7p21.1. The AGR3 gene is conserved in chimpanzee, Rhesus monkey, cow, mouse, rat, chicken, and frog.157 organisms have orthologs with human gene AGR3.